Copyright 2007 R. Klimek

"Cancer – final cellular form of life"

Rudolf Klimek, Dariusz Jasiczek, Piotr Gralek, Peter G. Fedor-Freibergh

Introduction
Cancer as an alternative of cellular death
Cancer as a signal of endangered health
Prevention and treatment of neoplastic disease
Conclusion
References


Summary

The essence of life is a constant spontaneous and mutual exchange of cellular matter and energy with information about their states as a unity. The problem is that life not arise de novo, but is only transferred, because life itself is more important than containing it the existing form. Cancer is the final cellular form of life in multi-cellular organisms, prolonging life processes of cell threatened by death. Its uniqueness lies in the fact that the self-organization of cancer cell can prolong only spontaneous life in daughter cells as long as the host organism is alive, due to the neoplastic dispersion of matter and energy, called dissipation.
Self-organized new cellular structures prolong their own existence at the expense of the duration of human life. Unfortunately neogenesis has proven to be a natural phenomenon, and as such we will never eliminate neoplastic diseases, but all hope lies in the prevention and destruction of neoplasm without concomitant increase of dissipative states in adjacent its surrounding cells. Therefore as soon as possible people should change their view of neoplasm to that of an effect of the loss of their human health. Each neoplastic disease possesses a variety of forms as well as a unique identity of the neoplasm as its own sufficing cause. This needs for an early detection, as well as an etiological treatment of pre-neoplastic states which can be ever more precisely detected with methods based on psychoneurocybernetics.

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Introduction

Medicine as no other field of human activity requires the specific responsibility for conscientious acquisition of general knowledge in order to understand all live events from the theoretical and practical point of view. The individual human live begins in utero as an indivisible continuum where each of the developmental stages is equally important in this continuum the unborn child and then newborns represent the indivisible entities of all functions on both physiological or physical, psychological and social levels. The intrauterine experiences (whether negative, positive or ambivalent in character) may in turn be revoked as informational sources during later life until death. Consequently, the prenatal period offers the unique opportunity for primary prevention of “physical” and “mental” distress and deprivation (2,3). For the first time five hundreds years ago Leonardo de Vinci introduced in his “Quaderni d’Anatomia” the quantitative outlook in the growth of the fetus in utero till 19 months after birth. Deplorable even nowadays there are many such information still too often not seen heard, read or only correctly understood and used (18,21). For example cancer, a name commonly used to describe neoplasm and/or neoplastic diseases, is linked with the public definitions of life, health and death as natural events. Interest in neoplasm can be found in a wide range of human occupation, ranging from philosophy and psychology to nanotechnology, combined into a new branch called psychoneurocybernetics. In this medicine takes a special place, especially gynecology which is not only concerned with human health from conception to death, but most importantly insures a natural inter-generational transfer of life to newborns from their grandparents and parents. The parents determine a unique genetic identity of their children, but already in the first and most important developmental step at level of the blastocyst the germinal cells of the potential mother and/or father begin an autonomous coexistence with all other somatic cells of each embryo and fetus. Therefore the protection and promotion of a woman’s health, not limited to prevention and treatment of diseases, is a distinguishing feature of this branch of medicine (1, 5-10).

The organism of the mother plays the most important part in the fetal and further psychobiological development of every individual human being. In effect, a woman’s bearing of the burden of pregnancy and birth is a natural condition for the fetus to reach maturity for autonomous life. Unfortunately, the state of the newborn is assessed solely by the Apgar scale, originally intended to scoring of post-partum breathing adaptation of the child. Of course this scale can be indirectly used to measure the fetal maturity, which however should be described with the number of technical quanta of said maturity, using six easily identifiable morphologically-functional features of the newborn. Calculation of maturity index can be done even by the mother herself, and not only by a midwife or a doctor. One needs only to know that a technical quantum relates to any arbitrary state or part of the examined feature, the multiple of which fits exactly without remainder in its entirety, such as, for example, the use of grams in reference to a kilogram of mass, millimeters to a meter’s length, cents to a dollar, or seconds to a minute. More importantly, the level of fetal maturity can be predicted already a few weeks before birth, using standard ultrasonographic equipment, together with appropriate software which has already been available since many years. Only a state of maturity given in the form of technical quanta is useful in determining the full maturity of the fetus, equaling the proper date of birth determined by the simultaneous disappearance of pregnancy tolerance on the side of the mother. Statistically determined date of birth cannot be used to determine the actual birth date, just as the Apgar scale cannot determine the future health of the children, especially those born operatively. From the natural occurrence of pregnancy and birth it can be inferred that there is no reason for gynecological procedures (including cesarean section and induction of labor) in more than 15% of all pregnancies, in other words values which exceed threefold beyond the scope of a normal distribution of natural events. Unfortunately, gynecologists cross this boundary for a variety of reasons, contrary to the primum non nocere (firstly do no harm) principle, although this is connected with increased hemorrhage, premature birth and post-pregnancy neuro-hormonal disturbances as well as an increased risk for all neoplastic diseases, not only cancer of the uterine cervix. Partly responsible for this are also women who insist on delivering the child via caesarian section without clinical indications. This is especially pertinent to women who improperly used anti-conception pills, which in the case of eventual pregnancy can increase risk of obstetrical and puerperal complications, lactation problems, in turn leading to a neoplastic disease. A review of these facts greatly facilitates the understanding of the essence of malignant transformation and development of the neoplastic disease as also a natural phenomenon (9-16).

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Cancer as an alternative of cellular death

After several decades of researches at the Jagiellonian University it has been shown that cancer is the final cellular form of life in multi-cellular organisms, prolonging life processes of cell threatened by death (10,14,15,18,19). Human being for maintaining his or her own existence executes internal as well as externally work to supply food and excrete metabolic products, as well as being involved in the social surroundings. In a similar way each cell, through its internal structures (organelles), works internally and externally in order for the whole system to function (Fig.1).



For a variety of reasons, sometimes even only from ageing, supply of substrates necessary for its metabolism may decrease in such way, that in order to survive the cell will have to limit its external functioning for the good of other cells for example the production of hormones, digestive enzymes, or even antibodies. In such a case the external work becomes limited to insuring the acquisition of only the necessary substances for the cells existence, and the function of cellular organelles needed for external work is inhibited. In the case of further limitations the cell, already in a state far from its internal equilibrium, begins to use matter and energy from the disintegration of its own non-functioning organelles, what is called apoptosis. In the end such a cell cannot exist any further, having exhausted even its own material-energetic resources. In this internal dissipathogenic states (far away from internal equilibrium) the alternative to cellular death is a reorganization into a new, yet efficient system, which at the same time must increase the chaos in its surroundings through a greater dissipation of matter and energy. Its uniqueness lies in the fact that the self-organization of cancer cell can prolong only spontaneous life in daughter cells as long as the host organism is alive, due to the neoplastic dispersion of matter and energy, called dissipation. The problem is that life not arise de novo, but is always only transferred. The essence of life is a constant spontaneous and mutual exchange of cellular matter and energy with information about their states as a unity. Matter, energy and information are the three basic properties of reality, of which only information is distinguished by its seeming ease of understanding the unity of verbal contradictions as seen in action and reaction, life and death, good and evil, night and day, left and right, up and down, north and south, etc. Difficulties arise only when trying to attempt to define each of the qualities on its own, just as any other concept, for example equality, which in mathematics is defined by a simple sign of equation or in physics the equality of mass and energy as denoted by Einstein’s E=mc2. Everything depends on the adopted limits of detail in the used concept in the understanding of the cellular or atomic structure of the organism, thereby unchanged in this remains the role of every cell as a whole with its sustenance of the material-energetic-information metabolism under the condition of reserving its extra functions in order to co-exist and cooperate with any remaining cells. Else, an under-performing cell must die or enhance its metabolism at the cost of dissipation the energy and matter in its environment through the phenomenon of self-organization of dissipative structures. Of course such a new entity (cancer) receives its own unique identity on a statistical basis, originating in equally unique organism. An adequate reason for the occurrence of cancer is extreme derangement of the cellular metabolism, called a dissipatogenic state, brought about by various reasons, like the natural ageing of the organism or several factors. Many of them can be the sufficient cause of more or less specific infectious, parasitic, adaptive, immunological, work-related and radiological diseases, but they alone are not enough for the emergence of cancer. Only on the level of thermodynamics can one compare viruses, genetic mutations, ultraviolet radiation, ageing, dietary components as well as the time and type of physical activity as different factors necessary to bring each cell to a dissipatogenic state, being then an adequate cause for the rise of cancer, which increases the dissipation of matter and energy in its surroundings. It is this dissipation which causes the ailments and the symptoms in neoplastic disease, ending in the destruction of the organism in the case of late or insufficient treatment, limited only to removing neoplastic changes without also removing and/or preventing pre-neoplastic (pre-dissipative) states.

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Cancer as a signal of endangered health

Emergent neoplastic cells are characterized by a dramatic increase of chaos in their surroundings, which is a lethal signal for the rest of the organism, announcing not only its metabolic failure, but also pertaining to its defensive and healing mechanisms. In a majority of such situations the organism itself as a whole first normalizes its local state, and if unsuccessful, initiates mechanisms for eliminating or at least only limited extend of neoplasm and its clones. Currently, using magnetic resonance imaging, one can view any part of the body through a spatial localization of its atoms. This allows the observation of material-energetic changes in the brain as a result of single words or even thoughts, dependant on the gender of the examined person. This proves the existence of roots of human life already on the level of primal elementary particles as basic space-time entities, which however do not lose their peculiar life after leaving the human body, or in the moment of entering the composition of a neoplasm being the end of material-energetic forms of life (18). Just atoms differ from each other through the sum of the elements they consist of, so cellular and organ-type forms of life built out of them, and finally autonomous organisms, are also a set of atoms whose number and relation to each other change in consecutive forms of life. One can differentiate between these structures on the basis of the functions they perform through supplying them with energy with the share of information, and not only on the basis of their spatial isolation from the first elementary particles which, devoid of mass, reclaim it as the temperature of the surroundings decreases, to the psycho-emotional state of a person with his/her free will in such complex spontaneous forms of social life as tribes, nations and countries, which is the topic of clinical psycho-neurocybernetics (5,19,21).

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Prevention and treatment of neoplastic disease

In cellular division an important role is played by multi-particle biochemical compounds: proteins and ribonucleic acids, which together or on their own can fulfill structural-energetic-informational functions. Structural DNA technology is already a separate field, as an effective technological system of simple dynamic structures linked with biology, what is a direct link between biology and non-animate matter. Scientists argue that the self-organization of a new system occurs in predictable fashion. This is one of the important new supporting proofs of thermodynamic interpretation of the cause and mechanism of the formation of neoplasm, what has been fully confirmed by clinical practice already 30 years ago (15,23,24,26). At the same time its natural essence requires a healthy lifestyle and a limiting of pathogenic factors, and an awareness of their causal link with the neoplastic disease. Among less wealthy persons one can detect a more aggressive and advanced state of the illness upon detection combined with a worse general health status. Therefore affective treatment must focus on strengthening the host’s defense mechanisms (not destroying them) and the elimination of alien neoplastic tissue and pathogenic factors, because the elimination of the cause(s) of each illness is more important than a therapy. In determining the cause, the most important issue is to determine the purpose of the occurrence of the caused effect (i.e. neoplasm), which is the subject of teleology, in order to avoid a wrong interpretation of events.

For example, the goal of infecting cells with the human papilloma virus (HPV) is the natural reproduction of the virus, whose proliferation is aided by the mucous state of the vaginal wall or mouth. If the viral infection causes a pathogenic state of a cell, it can lessen the possibility of reproduction due to corrupted cell function, or hasten its neoplastic transformation through a change in its genome through adding to it virus nucleotides. In reality a woman’s organism together with the Lactobacillus bacteria eliminates these viruses in 80% of cases. This means that the goal of an infection of cells through symbiotic microbes is not the emergence of neoplasm, but the creation of infectious illnesses for their own reproduction.

Neoplastic diseases are not contagious and may be classified as chronic diseases. For example cancer of the cervix is different from any infections disease, whereby causally related microbes assure their proliferation not limited to single organisms, while neoplasm live only in the organism they originated in. It is through teleology that a vaccination against a virus (more exactly against its protein component – a capsid) must not be called anti cancer. However, there exist individually selected anti-neoplastic vaccinations, produced on the basis of neoplastic cells detected in the organism. In an immuno-biochemic compromised organism a successful fight against one type of neoplasm does not prevent another neoplasm, also out of incompletely eliminated cells of the not yet defeated neoplasm. Currently it is possible to monitor the healing of neoplastic illnesses through direct assays of malignant genomes in peripheral blood, of course different from the genome of the patient genome.

Every natural event has its own immediate cause, the sense of which appears in the form of an effect, i.e. a structure or a process. This information linking the cause with the effect is for many people the abstraction, not being matter or energy - it plays an ever-increasing role in human life. Yet the lack of understanding of its functional meaning can cause even the death. In an example of media news about the death of a teenage person after an intramuscular prophylactic vaccination against Human Papilloma Virus (HPV) one can see that not only the material composition of the vaccine caused death, but the also information transmitted through its injection. This does not even pertain to legally forbidden commercial information or an untrue scientific description of the drug produced at the highest technological level, but to the real information contained in the composition of the vaccine.

HPV breeds only in the epithelial tissue, where the human defense mechanism is focused and therefore virus constantly changes its protein shell, called a capsid. In fact, rely always dangerous is penetration of virus beneath the epithelial tissue, of course together with its shell! People are then at high risk, which is especially dangerous to persons infected with other pathogens or using suppressing medication after an organ transplant. It is why for prophylactic purposes it has been decided to produce vaccines containing only the shells of two or four of very many types of this virus. They were called virus-similar instead of only analogous to the shell of the given type of HPV, whose viral nucleic component in not in the vaccine. Nevertheless anti-HPV vaccine composed only viral capsids of selected types of HPV can be dangerous because it conveys false information about containing genetic material of virus, which in reality is absent. Such solely protein information causes a deadly effect through its natural mobilization of the entire defense mechanism, which until then locally fought the presence of HPV only in the epithelial tissue! In the case of oversensitivity an acute and life-threatening reaction can take place. This fact proves the causal character of information itself, separated from the nucleic structure of the virus responsible for inflamed states and papilloma, and sometimes even conditioning a neoplastic transformation of infected cells.

In the cause-effect union of each event the cause always precedes the effect, whose existence is dependent upon various factors of the environment, in medicine often associated with the cause itself, e.g. neoplastic or infectious diseases. Of course no infectious illness can develop without the prior infection with a virus or bacteria as a single and specific cause, but every illness is results from the state of the human organism as well as the reaction to the infection from the side of saprophytic microorganisms, which is rarely taken under consideration. This pertains to, for example, both the HPV and HIV virus. The former lives in epithelial tissue cells and does not spread beyond them, while the latter infiltrates the immune system and destroys its cells. The prime goal of these infections is the replication of the viruses – the emergence of the illness is only secondary, i.e. inflammation and papilloma or the loss of immunity. In 80% of the cases the body can heal itself from an HPV infection, which has accompanied humankind for the longest time, and who can effectively combat it. The HIV epidemic has a much shorter history, because this virus began attacking human only after a mutation of its “animal” genome. On the other hand, the cause for the development of cancer, however, is a non-specific dissipathogenic state of an organism’s cell, and the number of factors leading a cell to this state is very large. Such an interpretation of the genesis of neoplasia was introduced in 1977 after 25 years of theoretical and clinical studies of a neurohormonal predisposition to cervical cancer, which then has been confirmed on the biophysical grounds using magnetic resonance imaging and spectroscopy (6,8,20-26). There are common thermodynamic roots of cervical cancer and premature delivery (7,13).

A meta-analysis of many medical papers showed in the last few decades an increase of cancer and no decrease in perinatal mortality or serious neonatal morbidity following delivery between 34 and 37 weeks of gestation in both developed and developing countries (4). Approximately two thirds of all premature deliveries occur spontaneously, but the remaining ones are due to medical diagnoses that warrant an early delivery, such as hypertension, diabetes, hemorrhage, fetal growth retardation, or also false “postdatism”. There are inverse relationships between the risk of spontaneous premature delivery and maternal age, socioeconomic status, educational level, and amount of prenatal care, but positive correlations with alcohol consumption, cigarette smoking per day, unmarried state during pregnancy, prior two or more induced abortions as well as prior preterm births and cervical intraepithelial neoplasia (CIN). It means that theretofore medical methods have reached their apogee and indicate that medicine has exhausted its possibilities. The decisive improvements on it can be achieved only by simultaneous medical and psychological cooperation. For example, the unexpected diagnosis of CIN in women seeking professional help due exclusively to infertility is a major emotional trauma, additionally intensified by direct medical manipulation of the uterine cervix. Eradication of cervical pathological changes, particularly cervical conization or amputation - additionally decrease fertility. In order to minimize this jeopardy it is possible to introduce medical treatment by immunotherapy in such cases (11,12,17). Cryosurgery, CO2-laser therapy or radical electrocautery are all effective in eradicating CIN, but not the dissipathogenic state (cancerogenic) of uterine tissues. This local ablative therapy must be followed by medical restoration of the body’s defense mechanism to prevent the recurrence of the disease. Only immunotherapy as a mean of treating the whole body can alone prevent and cure the dissipathogenic states, as a final causes of cancerogenesis of any part of the body, not only the uterine cervix. That is why humanities again should play a more important part in conquering “cancer of mothers” and preventing “cancer of early sexual life”. What is more, cancer as a natural stochastic phenomenon and disease can be promoted by many non-specific factors, including also such gynecological ones as:

1. faulty prediction and determination of birth data; 2. instrumental instead of possible natural labor; 3. reduction rather prolongation of lactation; 4. acceptation of early sexual life; 5. wrong hormonal therapy; 6. long-lasting prescription of pills, especially the same ones; 7. infrequent diagnosis and wrong therapy of hypothalamic conditioned abortions and premature deliveries; 8. clinical, colposcopic and cytologic false negative diagnosis of cervical cancer; 9. eradication of neoplastic lesion without normalization of its near-environment and 10. too radical and aggressive treatment of precancerous states.

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Conclusion

Increased dissipation of matter and energy by the neoplastic cell in a hitherto normal tissue is the first and non-specific, but universally recognized information about the local danger in the organism. A satisfactorily functioning organism can, through its defense mechanisms, not only destroy such a cell with alien neoplastic identity, but also remove dissipathogenic states in endangered cells of its own tissue. This happens constantly in multi-cellular organisms, and besides proliferation and apoptosis determines the size of cellular population in tissues and organs. From this perspective neogenesis is shown to be a regulator of the size and quality of tissues. A neoplasm as a dissipative structure has no history, because it begins its existence at the end of the life of a dissipathogenic cell, whose identity was still identical with healthy human cells. Every neoplastic cell differentiates itself through its identity from atypical cells of another clone, because their identities are picked stochastically as one of many possible types. The biological character of neogenesis as a self-organization of dissipative structures, however, precludes the possibility of a neoplasm existing autonomously apart from an individual organism, also with always unique identity, where it arise.
Cells are able to self reproduction as independent and basic elements of multi-cellular organisms. An exception are germ cells, which act in this way only after linking into a zygote, which occurs with the simultaneous death of a large number of other sperm and egg cells. This process however is safeguarded through the mother’s basic function of procreation, which uses the remaining cells which accompany fertilization for other indeterminate biological processes, because nature produces nothing without a purpose. Ultimately, instead of speaking of the demise of a cell, one can speak of its sudden (necrosis) or gradual death (apoptosis), meaning the loss of biological activity through the change of special form and not the composition of atoms building-up its structure. Life itself is more important than containing it the existing form of cells, which by self-organizing into new cellular structures prolong their own existence at the expense of the duration of human life. Unfortunately neogenesis has proven to be a natural phenomenon, and as such we will never eliminate neoplastic diseases, but all hope lies in the prevention and destruction of neoplasm without concomitant increase of dissipative states in adjacent its surrounding cells. Therefore as soon as possible people should change their view of neoplasm to that of an effect of the loss of their human health. During cancerogenesis a battle is fought between the organism of the ill and the neoplasm. The organism attempts to destroy the neoplasm and inversely, the neoplasm fights to survive and attempts to counteract the organism’s reaction. There ensues a typical battle between the old and the new, which is usually won by the malignant neoplasm, as the last evolutionary creation to ensure the cell’s continuing life. Each neoplastic disease possesses a variety of forms as well as a unique identity of the neoplasm as its own sufficing cause. This needs for an early detection, as well as an etiological treatment of pre-neoplastic states which can be ever more precisely detected with methods based on psychoneurocybernetics.

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